|
KMID : 0352720210450060717
|
|
Journal of Ginseng Research
2021 Volume.45 No. 6 p.717 ~ p.725
|
|
|
Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice
|
|
Kim Jin-Kyeong
Shin Kon-Kuk
Kim Hae-Yeop
Hong Yo-Han
Choi Woo-Ram
Kwak Yi-Seong
Han Chang-Kyun
Hyun Sun-Hee
Cho Jae-Youl
|
|
|
Abstract
|
|
|
Background: Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period.
Methods: The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis.
Results: KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1 (MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach.
Conclusion: The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice.
|
|
|
KEYWORD
|
|
|
Korean Red Ginseng (KRG), anti-inflammatory effect, autophagy, aging
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|